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CHENG Heping

  • Academician of the Chinese Academy of Sciences, Professor
  • Professor, College of Future Technology, Peking University
    Director, National Biomedical Imaging Center, Peking University
    Chief Scientist, China Multimodality and Trans-scale Biomedical Imaging Facility
  • 个人简介
    Professor Cheng is mainly engaged in the research of calcium signal and mitochondrial biomedical field, as well as the independent innovation and production of high-end biomedical instruments.
    1. Calcium signal research. In 1993, the basic unit of cellular calcium signal transduction "Calcium Spark" was discovered and named. The original paper of Science was praised as one of the "Ten Most Outstanding Myocardial Research Papers" in the history of the UK Physiological News. More than 10 members of the calcium spark family, such as calcium star, calcium hole and calcium flicker, were found successively, revealing their biological significance in physiological and pathological processes. At present, calcium spark has been written into more than ten international textbooks of physiology, medical physiology, cell biology and so on.
    2. Mitochondrial function research. It was found that the mitochondrial transient explosive superoxide generation mode - superoxide flash (mitochondrial flash, Mitoflash) (Cell, 2008) - is ubiquitous in eukaryotic cells, playing an important signaling function in energy metabolism, learning and memory and cellular oxidative stress. Relevant achievements were awarded the "Research Achievement Award" by the International Cardiac Society (2016).
    3. Scientific research instrument innovation. The team successfully developed a micro two-photon microscope weighing only 2.2 grams, which realized the observation of brain neurons and dendrites and dendritic spines in freely moving mice (Nature Methods, 2017). This achievement was awarded "Top Ten Progress in Chinese Science in 2017", and was selected as the annual method of Nature Methods in 2018 together with other technologies in the field.
  • 所授课程
    Integrated Experimental Course II (Compulsory, Major, 4 credits)
    Mitochondrial Frontier Research Forum (Elective, 3 credits)
    Progress in Physiology (Compulsory, 2 credits)
  • 获奖及荣誉
    2021 Guohua Outstanding Scholar Award, Peking University
    2020 Science and Technology Progress Award, Ho Liang Ho Li Foundation
    2018 Top Ten Scientific Advances in China in 2017 (Cheng Heping Team winning award title: "Developing a micro-microscopic imaging system that can realize free-state brain imaging")
    2018 Miniature two-photon imaging and related technologies in the field were selected as the 2018 Method of the Year "Free Behavior Animal Imaging Method" by Nature Methods.
    2017 First prize of Natural Science of the Ministry of Education (winning projects: Principles of cellular calcium signaling and pathological regulation; Second complete investigator)
    2017 Second prize of the National Natural Science Award (winning projects: Cellular calcium signaling and molecular regulation; Second complete investigator)
    2016 Research Achievement Award, International Society of Cardiology.
    2009 Changjiang Scholar Achievement Award (Life Science), Ministry of Education.
    1996 Finalist, Louis N. Arnold M. Katz Basic Science Research Prizes for Young Investigators
  • 教育背景
    1980.9 – 1984.7 B.S., Dept. of Mechanics, Peking University, Beijing, China
    Major: Applied mathematics and fluid dynamics
    1984.9 - 1987.7 2nd B.S., Dept. of Biology, Peking University, Beijing, China
    Major: Physiology
    1984.9 - 1987.7 M.S., Dept. of Mechanics, Peking University, Beijing, China
    Major: Bioengineering
    1989.9 - 1990.7 Ph.D. student, Univ. of Puerto Rico, San Juan, Puerto Rico
    1990.8 - 1995.4 Ph.D., Dept. of Physiology, School of Medicine, Univ. of Maryland at Baltimore, Baltimore, MD 21201
    Major: Physiology
  • 工作简历
    2020.12-present Director, National Biomedical lmaging Center, Peking University
    2019.05-present Dean, Nanjing Institute of Molecular Medicine, Peking University
    2005.01-present Professor, Institute of Molecular Medicine, Peking University
    2004.11-2006.01 Senior Investigator with tenure, Laboratory of Cardiovascular Science, NIA, NIH
    1998.06-2004.12 Visiting Researcher, State Key Laboratory of Biofilm and Membrane BioEngineering, Peking University
    1998.06-2004.11 Investigator, Laboratory of Cardiovascular Science, NIA, NIH
    1987.07-1989.07 Instructor, Dept. of Electrical Engineering, Peking University, China
    1995.08-1998.05 Senior Staff Fellow, Laboratory of Cardiovascular Science, NIA, NIH
  • 团队成员
    Researcher Wang Xianhua
    Assistant researcher Ma Qi
    Distinguished Research Associate Wu Runlong
    Distinguished Research Associate Zhang Jiabin
    Research Assistant Junjie Wang
    Postdoctoral Researcher Huang Haipeng
    Postdoctoral Researcher Xu Fengli
    Postdoctoral Researcher Dong Feihong
    Postdoctoral Researcher Zhao Chunzhu
    Postdoctoral Researcher Zhou Fangxu
    Engineer Wang Yanru
    Secretary Du Shuxin
  • 承担项目
    Since 2018, Chief Scientist, China Multimodality and Trans-scale Biomedical Imaging Facility
    Since 2019, Project Leader, Peking University-Nanjing Jiangbei New Area Joint Innovation Program
    2019.01 -2021.12, Project Leader, NSFC, Calcium Signaling Team of Innovation (Ⅲ)
    2016.01 -2018.12, Project Leader, NSFC, Calcium Signaling Team of Innovation (Ⅱ)
    2016.01-2021.12, Principal Investigator, NSFC, The Endoplasmic Reticulum-Mitochondria Coupling and Its Role in Energy Metabolism
    2014.01-2018.12, Chief Scientist, NSFC, High Space-time Resolution Miniature Two-photon Microscope for In Vivo Imaging
    2013.01 -2015.12, Project Leader, NSFC, Calcium Signaling Team of Innovation (I)
    2013.01-2017.08, Chief Scientist, MOST, Role and Mechanism of Mitochondrial Dysfunction in Early Pathogenesis of Heart Failure
    2012.01-2016.12, Principal Investigator, NSFC, Mechanisms and Functions of Mitochondrial Superoxide Flashes
    2011.01-2015.08, Principal Investigator, MOST, Spatiotemporal Dynamics of Cell Signaling
    2007.01-2010.12, Principal Investigator, MOST, Mechanism and Regulation of Cellular Calcium Signals
    2007.01-2011.08, Chief Scientist, MOST, Molecular Mechanisms and Early Intervention Strategies of Major Heart Diseases
  • 代表性论文及论著
    1. W Zong, R Wu*, S Chen, J Wu, H Wang, Z Zhao, G Chen, R Tu, D Wu, Y Hu, Y Xu, Y Wang, Z Duan, H Wu, Y Zhang, J Zhang, A Wang*, L Chen*, H Cheng. Miniature two-photon microscopy for enlarged field-of-view, multi-plane, and long-term brain imaging, Nature Methods, 2021, 18(1): 46-49.
    2. D Wu, W Qi, W Nie, Z Lu, Y Ye, J Li, T Sun, Y Zhu, H Cheng*, X Wang*. BacFlash signals acid-resistance gene expression in bacteria, Cell Research, 2021,31(6):703-712.
    3. F Lu*, Y Zhao, W Xie, Q Guo, S Wang, X Wang, H Cheng*. Imaging sarcoplasmic reticulum Ca2+ signaling in intact cardiac myocytes, Circulation, 2020, 142(15): 1503-1505.
    4. Y Yue, W Zong, X Li, J Li, Y Zhang, R Wu, YLiu, J Cui, Q Wang, Y Bian, X Yu, Y Liu, G Tan, Y Zhang, G Zhao, B Zhou, L Chen, W Xiao*, H Cheng*, A He*. Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution, Nature Cell Biology, 2020, 22(3): 332-340.
    5. Y Lin, L Li, W Nie, X Liu, A Adler, C Xiao, F Lu, L Wang, H Han, X Wang, W-B Gan*, H Cheng*. Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients. Nature Communications, 2019, 10(1): 5277.
    6. T Hou, R Zhang, C Jian, W Ding, Y Wang, S Ling, Q Ma, X Hu, H Cheng*, X Wang*. NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly, Cell Research, 2019, 29(9):754-766.
    7. X Wang*, X Zhang, D Wu, Z Huang, T Hou, C Jian, P Yu, F Lu, R Zhang, T Sun, J Li, W Qi, Y Wang, F Gao*, H Cheng. Mitochondrial flashes regulate ATP homeostasis in the heart, eLife, 2017, 6: e23908.
    8. W Zong, R Wu, M Li, Y Hu, Y Li, J Li, H Rong, H Wu, Y Xu, Y Lu, H Jia, M Fan, Z Zhou, Y Zhang*, A Wang*, L Chen*, H Cheng. Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice, Nature Methods, 2017, 14 (7): 713-719.
    9. Z Fu, X Tan, H Fang, P-M Lau, X Wang*, H Cheng*, G Bi*. Dendritic mitoflash as a putative signal for stabilizing long-term synaptic plasticity, Nature Communications, 2017, 8(1): 31.
    10. XH Wang*, X Zhang, ZL Huang, D Wu, BB Liu, RF Zhang, RK Yin, TT Hou, CS Jian, JJ Xu, Y Zhao, YR Wang, F Gao, H Cheng*. Protons trigger mitochondrial flashes. Biophysical Journal, 2016, 111 (2): 386-394.
    11. W Shang, F Lu, T Sun, J Xu, L-L Li, Y Wang, G Wang, L Chen, X Wang, M B Cannell, S-Q Wang*, H Cheng*. Imaging Ca2+ nanosparks in heart with a new targeted biosensor, Circulation Research, 2014, 114(3): 412-420.
    12. E-Z Shen, C-Q Song, Y Lin, W-H Zhang, P-F Su, W-Y Liu, P Zhang, J Xu, N Lin, C Zhan, X Wang, Y Shyr, H Cheng*, M-Q Dong*. Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans, Nature, 2014, 508(7494): 128-132.
    13. C Wei*, X Wang, M Chen, K Ouyang, L-S Song, H Cheng*. Calcium flickers steer cell migration, Nature, 2009, 457(7231): 901-905.
    14. W Wang*, H Fang, L Groom, A Cheng, W Zhang, J Liu, X Wang, K Li, P Han, M Zheng, J Yin, W Wang, M P Mattson, J P Y Kao, E G Lakatta, S-S Sheu, K Ouyang, J Chen, R T Dirksen, H Cheng*. Superoxide flashes in single mitochondria, Cell, 2008, 134(2): 279-290.
    15. H Cheng*, W J Lederer. Calcium sparks, Physiological Reviews, 2008, 88(4): 1491-1545.
    16. D X P Brochet , D Yang*, A D Maio, W J Lederer, C Franzini-Armstrong, H Cheng*. Ca2+ blinks: rapid nanoscopic store calcium signaling, Proc Natl Acad Sci USA, 2005, 102(8): 3099-3104.
    17. S Wang, L Song, E G Lakatta, H Cheng*. Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells, Nature, 2001, 410(6828): 592-596.
    18. M G Klein, H Cheng*, L F Santana, Y Jiang, W J Lederer, M F Schneider. Two mechanisms of quantized calcium release in skeletal muscle, Nature, 1996, 379(6564): 455-458.
    19. H Cheng, M Fill, H H Valdivia, W J Lederer. Models of calcium release channel adaptation, Science, 1995, 267(5206): 2009-2010.
    20. H Cheng, W J Lederer*, M B Cannell. Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle, Science, 1993, 262(5134):740-744.