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  • 办公地址：

    Room 415, Integrated Science Research Center No.2

  • 联系电话：

    010-62757963

  • 电子邮箱：

    zhixingchen@pku.edu.cn

  • 个人网页：

    http://zhixingchenlab.mysxl.cn

CHEN Zhixing

  • Principal Investigator, Doctoral Advisor
  • Institute of Molecular Medicine, College of Future Technology, Peking University
    Center for Life Sciences, Peking University - Tsinghua University
    National Biomedical Imaging Science Center, Peking University
  • 个人简介
    As an emerging interdisciplinary field, biological imaging is driving the progress of life science and medical research at a revolutionary pace. We are committed to integrating advanced technologies in organic synthesis, spectroscopy, polymer chemistry and chemical biology from a molecular perspective to develop a new generation of imaging probes based on small molecules, polymers and biomacromolecules, providing handy and even indispensable tools for research in biophysics, cell biology, physiology and metabolism, and ultimately illuminating the way for new drug development.
    The uniqueness of our research lies in: 1. Based on chemical principles, tailored small molecules, polymers and biomacromolecules probes as solutions for the pain points in imaging and other fields; 2. Relying on the cooperation platform of Institute of Molecular Medicine and Joint Center for Life Sciences, we combine modern molecular technology with the most cutting-edge life science problems; 3. We provide training in chemistry and biotechnology, interdisciplinary cooperation experience and problem solver's thinking mode.
    The long-term goal of the laboratory is to practice the concept of "integrated innovation" and the strategy of "from molecule to human", by developing diverse, precise and exquisite molecular tools, to promote all aspects of basic research in life sciences and to contribute to the benefit of human health.
  • 所授课程
    Fundamentals of Chemistry (Integrated Science) (Compulsory, 4 credits)
    Frontiers in Chemical Biotechnology and Bioimaging (General Elective course, 3 credits)
    Recent advance in bioimaging probes (General Elective course, 3 credits)
  • 获奖及荣誉
    Green-Leaf Biomedicine Outstanding Young Scholar Award
    Boya Young scholar, Peking University
  • 个人履历
    2018-now CLS Investigator, Peking-Tsinghua Center for Life Sciences, Peking University
    2016-2018 Postdoctoral Researcher, Department of Chemistry, Stanford University
    2015 Postdoctoral Fellow, Columbia University
    2009-2014 PhD, Columbia University, USA
    2004-2008, Bachelor of Science, Tsinghua University
  • 承担项目
    Project of National Natural Science Foundation (host)
    Life Science Frontier Innovation Cultivation Project of Beijing Science and Technology Commission (host)
    National Key Research and Development Plan (participate)
  • 代表性论文及论著
    1. Mo, J.#; Chen, J.#; Shi, Y.; Sun, J.; Wu, Y.; Liu, T.; Zhang, J.; Zheng, Y.; Li, Y.; Chen, Z.* Third-Generation Covalent TMP-Tag for Fast Labeling and Multiplexed Imaging of Cellular Proteins. Angew. Chem. Int. Ed. 2022, 61, e202207905.
    2. Liu, M.#; Zhang, J.#; Chen, Z.* Emerging trends in fluorescence bioimaging of divalent metal cations using small-molecule indicators. Chem. Eur. J. 2022, 28, e202200587. [Invited Review]
    3. Du, J.; Zheng, L.; Gao, P.; Yang, H.; Yang, W.-J.; Guo, F.; Liang, R.; Feng, M.; Wang, Z.; Zhang, Z.; Bai, L.; Bu, Y.; Xing, S.; Zheng, W.; Wang, X.; Quan, L.; Hu, X.; Wu, H.; Chen, Z.; Chen, L.; Wei, K.; Zhang, Z.; Zhu, X.; Zhang, X.; Tu, Q.; Zhao, S.-M.*; Lei, X.*; Xiong, J.-W.* A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell 2022, 29, 545-58.
    4. Niu, Y.; Liu, R.; Guan, C.; Zhang, Y.; Chen, Z.; Hoerer, S.; Nar, H.; Chen, L.* Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter. Nature 2022, 601, 280-4.
    5. Zhang, J.#; Peng, X.#; Wu, Y.#; Ren, H.#; Sun, J.; Tong, S.; Liu, T.; Zhao, Y.; Wang, S.; Tang, C.; Chen, L.; Chen, Z.* Red- and Far-Red-Emitting Zinc Probes with Minimal Phototoxicity for Multiplexed Recording of Orchestrated Insulin Secretion. Angew. Chem. Int. Ed. 2021, 60, 25846-55. [Inside Cover]
    6. Yang, Z.#; Li, L.#; Ling, J.; Liu, T.; Huang, X.; Ying, Y.; Zhao, Y.; Zhao, Y.; Lei, K.*; Chen, L.*; Chen, Z.* Cyclooctatetraene-conjugated cyanine mitochondrial probes minimize phototoxicity in fluorescence and nanoscopic imaging. Chem. Sci. 2020, 11, 8506-8516.
    7. Chen, Z.#; Zhu, X.#; Yang, J.; Mercer, J. A. M.; Burns, N. Z.; Martinez, T. J.; Xia, Y. The cascade unzipping of ladderane reveals dynamic effects in mechanochemistry. Nat. Chem. 2020, 12, 302-309.
    8. Chen, Z.; Mercer, J. A. M.; Zhu, X.; Romaniuk, J. A. H.; Pfattner, R.; Cegelski, L.; Martinez, T. J.; Burns, N. Z.; Xia, Y. Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene. Science 2017, 357, 475-479. [Front Cover].
    9. Wei, L.; Chen, Z.; Shi, L.; Long, R.; Anzalone, A. V.; Zhang, L.; Hu, F.; Yuste, R.; Cornish, V. W.; Min, W. Super-multiplex vibrational imaging. Nature 2017, 544, 465-470.
    10. Chen, Z.; Paley, D. W.; Wei, L.; Weisman, A. L.; Friesner, R. A.; Nuckolls, C.; Min, W. Multicolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational Palette. J. Am. Chem. Soc. 2014, 136, 8027–8033.
    11. Chen, Z.; Cornish, V. W.; Min, W. Chemical Tags: Inspiration for Advanced Imaging Techniques. Curr. Opin. Chem. Biol. 2013, 17, 637–643.
    12. Chen, Z.; Jing, C.; Gallagher, S. S.; Sheetz, M. P.; Cornish, V. W. Second-Generation Covalent TMP-Tag for Live Cell Imaging. J. Am. Chem. Soc. 2012, 134, 13692–13699.
    13. Chen, Z.#; Wei, L.#; Zhu, X.#; Min, W. Extending the Fundamental Imaging-Depth Limit of Multi-Photon Microscopy by Imaging with Photo-Activatable Fluorophores. Opt. Express 2012, 20, 18525–18536.