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WANG Jing

  • Researcher, Associate Professor, Doctoral supervisor
  • Department of Chemical Biology, School of Pharmacy, Peking University

    National key laboratory of Natural Medicine and bionic medicine

    National Biomedical Imaging Center, Peking University
  • 个人简介
    The group's research involves a wide range of chemical biology studies, including the development of novel methods of chemical marker sequencing of nucleic acid epigenetic modification and clinical diagnosis, the application of genetically coded fluorescent probes in tumor metabolism and neural networks, and the study of tumor immune function mechanisms and chemical interventions containing copper proteins.

    1. Develop molecular probes for small molecules of signal transduction and study their regulatory mechanisms through proteomics, high-throughput sequencing and other technologies;

    2. Fluorescent protein probe (Biosensor) and super-resolution microscopic imaging targeting tumor endogenous metabolic molecules;

    3. Discovery and confirmation of novel anti-tumor targets and lead compounds.
  • 所授课程
    Organic Chemistry (compulsory, 3 credits)

    Introduction to Chemical Biology (compulsory, 2 credits)

    Cell Biology (compulsory, 2 credits)
  • 获奖及荣誉
    Overseas high-level Young talents, Luye Biomedicine Outstanding Young Scholars Award, Peking University Liberal Arts Young Scholars, Peking University Medical Youth Science and Technology
  • 个人履历
    2022- Now Associate Professor, Researcher, School of Pharmacy, Peking University

    2016-2021 Assistant Professor, Distinguished Researcher, School of Pharmacy, Peking University

    2009-2015 Postdoctoral Fellow, University of Chicago, USA

    2004-2009 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PhD

    2000-2004, Bachelor, Soochow University
  • 承担项目
    Three National Natural Science Foundation Projects (hosted)

    Two National Key R&D Programs (participation)
  • 代表性论文及论著
    1. Liu, C.+, Sun, H.X.+, Yi, Y.P.+, Shen, W.G.+, Li, K.+, Li, F., Xiao, Y., Li, Y.C., Hou, Y.K., Men, H.W., Peng, J.Y., Yi, C.Q.*, Wang. J.* Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI. Nat. Biotechnol., 2023, 41,355-366.


    2. Zhang, M.Q.+, Yang, B.+, Zhang, J.Y., Song, Y.X., Wang, W.B., Li, N., Wang, Y., Li, W.Z, Wang, J.* Monitoring the Dynamic Regulation of the Mitochondrial GTP-to-GDP Ratio with a Genetically Encoded Fluorescent Biosensor. Angew. Chem. Int. Ed., 2022, 61, e202201266.


    3. Ding, F.X., Li, F., Tang, D.S., Wang, B., Liu, J.Y., Mao, X.Y., Yin, J.Y., Xiao, H.H.*, Wang, J.*, Liu, Z.Q.* Restoration of the Immunogenicity of Tumor Cells for Enhanced Cancer Therapy via Nanoparticle-Mediated Copper Chaperone Inhibition. Angew. Chem. Int. Ed., 2022, 61, e202203546.


    4. Chen, L.+, Li, N.+, Zhang, M.Q.+, Sun, M.M., Bian, J.X., Yang, B., Li, Z.C.X., Wang, J.Y., Li, F., Shi, X.M., Wang, Y., Yuan, F., Zou, P., Shan, C.L., Wang, J.* APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation. Angew. Chem. Int. Ed., 2021, 60, 25346-25355 (VIP).


    5. Wang, W.B.+, Wei, Q.P.+, Zhang, J.Y., Zhang, M.Q, Wang, C.C., Qu, R.Y., Wang, Y., Yang, G.F.*, Wang J.* A Ratiometric Fluorescent Biosensor Reveals Dynamic Regulation of Long-Chain Fatty Acyl-CoA Esters Metabolism. Angew. Chem. Int. Ed., 2021, 60, 13996-14004 (Hot paper).


    6. Wang, J.+, Luo, C.+, Shan, C.L.+, You, Q.C.+, Lu, J.Y., Elf, S., Zhou, Y., Wen, Y., Xie, Y.X., Vinkenborg, J.L., Fan, J., Kang, H.B., Lin, R.T., Han, D.L., Karpus, J., Chen, S.J., Ouyang, S.S., Luan, C.H., Zhang, N.X., Merkx, M., Liu, H.; Chen, J.*, Jiang, H.L.*, He, C.* Inhibition of human copper trafficking significantly attenuates tumor growth. Nat. Chem., 2015, 7, 968–979.


    7. Wang, J., Karpus, J., Zhao, B. S., Luo, Z., Chen, P. R., He, C.* A selective fluorescent probe for carbon monoxide imaging in living cells. Angew. Chem. Int. Ed., 2012, 51, 9652-9656.


    8. Song, C.X., Szulwach, K.E., Fu, Y., Dia, Q., Yi, C., Li, X., Li, Y., Chen, C.H., Zhang, W., Jian, X., Wang, J., Zhang, L., Looney, T.J., Zhang, B., Godley, L.A., Hicks, L.M., Lahn, B.T.*, Jin, P.*, He, C.* Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol., 2011, 29, 68-72.