• Principal Investigator, Doctoral Advisor
• Institute of modern optics, School of Physics
  National Biomedical Imaging Center

• 个人简介

  Shi's recent work include: Development of many new bio-photonics imaging and spectroscopy technologies based on the research of new mechanisms and novel optical techniques on light field regulation. Through exploration and application of light wavefront, phase and electromagnetic spectrum regulation, combined with a variety of optical mechanisms, he has made a series of original achievements in the fields of high spatio-temporal resolution unlabeled optical diffraction tomography (ODT) living cell imaging, super resolution stimulated radiation loss (STED) fluorescence imaging and femtosecond laser frequency comb high-precision phase imaging detection. For the first time, ODT imaging mode and super resolution fluorescence imaging mode were combined for living cell imaging, and a dual-mode in situ, co-positioning high spatio-temporal resolution imaging system was designed and developed. He proposed the Super resolution fluorescence-assisted diffraction tomography (SR-FACT) imaging technique, which can simultaneously perform fluorescence and unlabeled imaging on the same living cells, realizing the ability to combine intracellular panoramic imaging with specific molecular imaging. The SR-FACT system was successfully used to conduct co-localization imaging of six major organelles in living cells, and demonstrated its unique advantages in studying organelle interactions, providing a powerful tool for the comprehensive three-dimensional characterization of organelle interactions and molecular or information transfer processes in living cells. He has published more than 100 SCI papers in Light, Physical Review Letters, Laser & Photonics Reviews, PNAS, Optics Letters and other high-level academic journals, citation more than 1800 times, h factor 26. He has presided over 7 major instrument projects of the Ministry of Science and Technology, key projects of the Foundation and major research plan integration projects. In 2013, he was awarded the Outstanding Youth Science Foundation of the National Foundation of China. He was invited to report at international and domestic academic conferences up to 48 times, including 19 invited reports at international conferences; He is also member of the organization of several international conferences. Since 2014, he has been the Co-Chair of the International Conference on "Ultrafast Imaging and Spectroscopy" at the Annual Conference of the International Optical and Photonics Association (SPIE) and a member of the organizing committee of the Asian Photonics Conference of the International Optical and Photonics Association (SPIE). He is the editorial board for Photonics Research Journal of the OPTICA Society since 2019.

• 所授课程

  Ultrafast Lasers and Spectra (Elective, 2 credits)
  General Physics Experiment 2 (Compulsory, 2 credits)
  Optics, Discussion Class (Compulsory, 2 credits)

• 获奖及荣誉

  Winner of National Science Fund for Distinguished Young Scholars

• 教育背景

  2007 PhD, Department of Electrical Engineering, Pennsylvania State University
  2001 Master, Department of Optoelectronic Information Science, Nankai University
  1998 Bachelor, Department of Opto-electronic Information Science, Nankai University

• 工作简历

  Jul. 2011 -- present, Researcher, doctoral supervisor, Institute of Modern Optics, School of Physics, Peking University
  January 2008 -- May 2011 Postdoctoral Researcher, Department of Electrical Engineering, Pennsylvania State University, USA
  August 2001 -- August 2003 Engineer in Shenzhen Huawei Technologies Co., LTD

• 承担项目

  2022-2024, Major Research Program of Optical field Regulation, Integrated Project, "New Technology and Application Research of Multi-mode High-speed Super Resolution Optical Imaging"
  2018-2021, Major Research Program of Optical field Regulation of the National Foundation of China, with the key project "New Technology and Application Research of Optical Imaging Based on Optical Field Regulation"
  2012-2015, National Natural Science Foundation of China Project "Holographic Anti-Stokes Raman Imaging"
  2014-2016, "Nonlinear Optical Imaging Technology Research", National Natural Science Foundation of China Outstanding Youth Science Foundation
  2012-2017, National Major Instrument Research and Development Project of the Ministry of Science and Technology, "Femtosecond fiber laser"

• 代表性论文及论著

  1. Yanhui Cai#, Yizhu Chen#, Yiqiu Xia, SiYang Zheng, Zhiwen Liu and Kebin Shi*, “Single-lens light-sheet fluorescence microscopy based on micro-mirror array,” Laser & Photonics Reviews, 2100026, (2022).
  2. Wenkai Yang, Lige Liu*, Dashan Dong, Yunan Gao, Hong Yang, Qihuang Gong and Kebin Shi*, “In Situ Three-Dimensional Observation of Perovskite Crystallization Revealed by Two-Photon Fluorescence Imaging,” Advanced Optical Materials, 2200089, (2022).
  3. Yanhui Cai#, Wei Liu#, Wenkai Yang, Jian Xu, Hong Yang and Kebin Shi*, “Differential fluorescence microscopy by using a dynamic cylindrical-vector field”, Opt. Lett. 46, 2332-2335 (2021).
  4. Wei Liu, Dashan Dong, Hong Yang, Qihuang Gong, Kebin Shi*, “Robust and high-speed rotation control in optical tweezers by using polarization synthesis based on heterodyne interference,” Opto-Electron Adv 3, 200022 (2020).
  ​5. Dashan Dong, Xiaoshuai Huang, Liuju Li, Heng Mao, Yanquan Mo, Guangyi Zhang, Zhe Zhang, Jaiyu Shen, Wei Liu, Zeming Wu, Guanghui Liu, Yanmei Liu, Hong Yang, Qihuang Gong, Kebin Shi* and Liangyi Chen*, “Super-resolution fluorescence-assisted diffraction computational tomography reveals the three-dimensional landscape of the cellular organelle interactome,” Light, science & applications 9, 11 (2020).