中文
中文
Faculty
Home >> Faculty >> Researchers

WANG Shiqiang

  • Professor
  • Changjiang Distinguished Professor, School of Life Sciences, Peking University
    National Biomedical Imaging Center
  • 个人简介
    Dr. Wang’s studies have been focused on the molecular basis of intracellular Ca2+ signaling. He combines state-of-the-art confocal imaging, single-channel patch clamping, single-molecule tracing with molecular cell biology techniques to dissect the molecular mechanisms underlying the generation, amplification and termination of intracellular Ca2+ dynamics, aiming to answer important questions about the function, development and dysfunction of the heart.
    Abnormal calcium signal transduction is closely related to heart failure, arrhythmia and other important diseases. We have made a breakthrough in the molecular pathological mechanism of heart failure. We found that the pathological changes of the molecular process of calcium signaling are much earlier than the functional changes of cells and myocardial tissue. We elucidated the molecular mechanism and proposed a new idea to reverse the pathological changes. The mutual regulation of nerve and heart is closely related to human health and behavior. We systematically elucidate the signal transduction principle of sympathetic neurotransmitter regulating calcium signal in cardiomyocytes and propose a new "offside blocking" theory of different signal pathways regulating β1 adrenergic receptor. On this basis, we will further investigate the relationship between neuroregulation and heart disease, development and regeneration.
  • 所授课程
    Physiology (Compulsory, 3 credits)
  • 获奖及荣誉
    Winner of The National Science Fund for Distinguished Young Scholars, Chang Hsi-chun Young Investigator Prize by Chinese Association for Physiological Sciences, National 10000 Leading Scholar Plan, Second Prize of National Natural Science, First Prize of Natural Science by the Ministry of Education, Excellent Teacher of Beijing, National Outstanding Scientist of Science and Technology, Special Government Allowance of The State Council, Richard J. Bing Young Investigator Award by International Society for Heart Research, Katz Basic Science Research Prize by American Heart Association, Zhang Xijun Award by the Chinese Physiological Society, etc
  • 个人履历
    2013 - present, Vice-Principal, College of Life Sciences, Peking University
    2003 - present, Professor, College of Life Sciences, Peking University
    2002-2017, Vice-chairman, Chairman, National Key Laboratory of Membrane Biology
    1999-2003 Postdoctoral Researcher and Visiting Scholar, Institute on Aging, National Institute of Health, US
    1992-1998, Ph.D., Physiology, Peking University
    1990-2003, Assistant, Lecturer, Associate Professor, School of Life Sciences
    1986-1990, B.S., Physiology & Biophysics, Peking University
  • 团队成员
    HOU Tingting, Assistant Researcher
  • 承担项目
    Key project of National Science Foundation, Major research plan
  • 代表性论文及论著
    1. Yang L, Li RC, Xiang B, Li YC, Wang LP, Guo YB, Liang JH, Wang XT, Hou T, Xing X, Zhou ZQ, Ye H, Feng RQ, Lakatta EG, Chai Z, Wang SQ*. Transcriptional regulation of intermolecular Ca2+ signaling in ground squirrel cardiomyocytes: the myocardin- junctophilin axis. Proc. Natl. Acad. Sci. U.S.A. 2021;118, e2025333118.
    2. Li LL, Guo QJ, Lou HY, Liang JH, Yang Y, Xing X, Li HT, Han J, Shen S, Li H, Ye H, Di Wu H, Cui B, Wang SQ* (2020) Nanobar Array Assay Revealed Complementary Roles of BIN1 Splice Isoforms in Cardiac T-Tubule Morphogenesis. Nano Lett. 20(9):6387-6395.(Cover story)
    3. Ji GS, Hou T, Zhang Y, Xiao RP, Wang SQ* (2019)β2-Adrenergic Stimulation Compartmentalizes β1 Signaling into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors. Circ Res. 124(9):1350-1359. (Highlighted)
    4. Zhao YT, Guo YB, Gu L, Fan XX, Yang HQ, Chen Z, Zhou P, Yuan Q, Ji G, Wang SQ (2017) Sensitized signaling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. Cardiov. Res., 113(3):332-342. (Editorial Highlighted)
    5. Rong J, Han J, Dong L, Tan Y, Yang H, Feng L, Wang QW, Meng R, Zhao J, Wang SQ*, Chen X* (2014) Glycan imaging in intact rat hearts and glycoproteomic analysis reveal the upregulation of sialylation during cardiac hypertrophy. J. Am. Chem. Soc. 136(50): 17468-17476.
    6. Li RC, Tao J, Guo YB, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M*, Wang SQ* (2013) In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice. Circ. Res. 112 (4): 601-605.
    7. Xu M, Wu HD, Li RC, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST, Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y, Xi JZ J., Gao W, Han QD, Zhang YY, Wang XJ, Meng X, and Wang SQ* (2012) MiR-24 regulates junctophilin-2 expression in cardiomyocytes. Circ. Res. 111:837– 841. (editorial Highlighted).
    8. Zhou P, Zhao YT, Guo YB, Xu SM, Bai SH, Lakatta EG, Cheng H, Hao XM, Wang SQ* (2009) b-Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel. Proc. Natl. Acad. Sci. U. S. A. 106: 18028-18033.
    9. Xu M, Zhou P, Xu SM, Liu Y, Feng XH, Bai SH, Bai Y, Hao XM, Han QD, Zhang YY, Wang SQ* (2007) intermolecular Failure of L-type Ca2+ Channel and Ryanodine Receptor Signaling in Hypertrophy. PLoS Biol. 5: e21,0203-0211 (Highlighted by: Harrison C. Heart disease: Unmasking molecular mechanisms. Nat. Rev. Drug Disc. 6: 271, 2007).
    10. Wang SQ, Song LS, Lakatta EG, Cheng H* (2001). Ca2+ signaling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature, 410: 592-596.