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Daniel Choquet

  • Dr., Research Director
  • Visiting Endowed Professor，National Biomedical Imaging Center, Peking University
    Research Director, CNRS
    Former Director, Institute for Interdisciplinary Neuroscience (UMR 5297, CNRS‑Université de Bordeaux)
    Director, Bordeaux Imaging Center
    Director of excellence cluster BRAIN_2030
  • 个人简介
    His research focuses on dynamic synaptic organization, neurotransmitter receptor trafficking, synaptic plasticity and nanoscale super‑resolution imaging in neuroscience.
    His landmark discovery demonstrated that neurotransmitter receptors undergo constant lateral diffusion on neuronal plasma membrane, and receptor trafficking critically shapes synaptic transmission, reshaping the classical view of synapses.
    Combining neuroscience, physics and chemical biology, his group employs super‑resolution microscopy, single‑molecule tracking, electrophysiology and protein engineering to dissect nanomolecular assemblies at synapses underlying learning, memory and synaptic dysfunction in neurodevelopmental and psychiatric disorders. He has been awarded three Advanced ERC grants. He is member of French Academy of Sciences, EMBO and Academia Europa.
  • 所授课程
    Cajal Courses; Master in BioImaging; Master in Neuroscience
  • 获奖及荣誉
    2022 Grand prix de l’Académie nationale des sciences belles lettres et arts de Bordeaux
    2021 Officier de l'ordre national des Palmes Académiques
    2018 Presidential conference SFN 2018 San Diego; Prix « La Recherche » (Neuroscience); Advanced ERC Grant
    2016 Chevalier de la légion d’honneur
    2015 Member of Academia Europa
    2014 Member of EMBO
    2013 Advanced ERC grant
    2012 Chevalier de l'ordre national des Palmes Académiques
    2010 Member of the French Academy of Sciences; Prix de la découverte science (Bordeaux Academy)
    2009 Silver Medal, CNRS
    2008 Advanced ERC grant
    2004 Grand prix from the French Academy of Sciences (Prix du CEA)
    1997 Research prize from Fondation pour la Recherche Médicale
    1990 Bronze Medal, CNRS
  • 教育背景
    1997 Habilitation à diriger des recherches, University of Bordeaux
    1988 PhD in Pharmacology, University Paris VI (Supervisor: Dr. H. Korn, Institut Pasteur)
    1985 Master degree in Neurobiology, University Paris VI
    1984 Diploma in Bio‑engineering, Ecole Centrale des Arts et Manufactures de Paris
  • 工作简历
    2023‑present Member of the CNRS scientific council
    2021‑present Director of excellence cluster BRAIN_2030
    2024 Visiting Professor, Anschutz Medical Center, University of Colorado Denver, USA
    2020‑2023 Adjunct director of France BioImaging
    2009‑present Director, Bordeaux Imaging Center
    2011‑2023 Director, Institute for Interdisciplinary Neuroscience, UMR5297 CNRS‑Univ. Bordeaux
    1998‑present Research Director, CNRS
    1994‑1996 Postdoctoral Fellow, Duke University, USA (EMBO fellowship)
    1990 Postdoctoral Fellow, University of California Irvine, USA
    1988‑1998 Research Officer, CNRS
  • 团队成员
    Matthieu Sainlos (Research Director), Anna Brachet (Research Officer), Christelle Breillat (Research engineer), Sophie Daburon (Research Engineer), Chloe Dias (Post‑doc), Attila Ignasz (Post‑Doc), Regginald Edwards (Post‑Doc), Chiara Galizia (PhD Student), Chloe Cuenot (PhD Student), Anna Kolokotroni (PhD Student)
  • 承担项目
    1. How AMPA receptor dynamics shape short‑term plasticity and neuronal information processing
    2. Deciphering anchoring mechanisms stabilizing synaptic receptors supporting memory
    3. How neuronal pentraxins protect synapses from complement‑mediated elimination
    4. Bidirectional synaptic signaling mediated by planar cell polarity proteins and APP, and its disruption in Alzheimer’s disease
    5. Mapping nanoscale architecture of protein assemblies at synapses and cell‑adhesion sites
  • 代表性论文及论著
    1. Nowacka A, et al. Synapse‑specific and plasticity‑regulated AMPA receptor mobility tunes synaptic integration. Neuron, 2026.

    2. Getz A M, et al. High‑resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning. Science Advances, 2022.

    3. Bessa‑Neto D, et al. Bioorthogonal labeling of transmembrane proteins with non‑canonical amino acids unveils masked epitopes in live neurons. Nat Commun, 2021.

    4. Groc L, Choquet D. Linking glutamate receptor movements and synapse function. Science, 2020.

    5. Penn A C, et al. Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature, 2017.

    6. Nair D, et al. Super‑Resolution Imaging Reveals That AMPA Receptors Inside Synapses Are Dynamically Organized in Nanodomains Regulated by PSD95. J Neurosci, 2013.

    7. Heine M, et al. Surface Mobility of Post‑synaptic AMPARs Tunes Synaptic Transmission. Science, 2008.