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  • 办公地址：

    National Biomedical Imaging Center, College of Future Technology, Peking University

  • 电子邮箱：

    shan.zhao@pku.edu.cn

  • 个人网页：

    https://zhaolab-pku.github.io/

ZHAO Shan

  • Principal Investigator, Ph.D. Advisor
  • College of Future Technology, Peking University
    National Biomedical Imaging Center, Peking University
  • 个人简介
    The molecular and structural research of holistic organisms aims to comprehensively delineate their composition, structure, function and interrelationship at the molecular, cellular, tissue and organ levels. Dr. Zhao's laboratory is committed to elucidating the molecular and structural details of organism that governing physiological and pathological changes, by developing 3D multi-omics technologies that combining whole organ transparency, advanced imaging system (e.g. light-sheet) and deep-learning analysis for a wide range of biomedical studies, including Cancer and Microbiome, Stroke, Quantitative Medicine, etc.
  • 所授课程
    Advanced Course in Molecular Medicine (1 Lecture)
  • 获奖及荣誉
    Chinese Government Award for Outstanding Self-Financed Students Abroad
  • 教育背景
    2003-2007 Bs Pharmaceutical Engineering and Technology, Beijing Institute of Technology
    2007-2009 Ms Applied Chemistry, Beijing Institute of Technology
    2017-2020 Ph.D. Medical Research, Ludwig-Maximilians-Universität München
  • 工作简历
    2010–2013 Research Assistant, Tsinghua University
    2013–2017 Research Assistant, Peking University
    2021-2024 Postdoc, University of Zürich/ETH Zürich,
    2024– now Investigator, National Biomedical Imaging Center, Peking University
  • 代表性论文及论著
    1.Jie Luo*; Muge Molbay*; Ying Chen*; Izabela Horvath*; Karoline Kadletz*; Benjamin Kick*; Shan Zhao*; Rami Al-Maskari; Inderjeet Singh; Mayar Ali; Harsharan Singh Bhatia; David-Paul Minde; Moritz Negwer; Luciano Hoeher; Gian Marco Calandra; Bernhard Groschup; Jinpeng Su; Ceren Kimna; Zhouyi Rong; Nikolas Galensowske; Mihail Ivilinov Todorov; Denise Jeridi; Tzu-Lun Ohn; Stefan Roth; Alba Simats; Vikramjeet Singh; Igor Khalin; Chenchen Pan; Bernardo A. Arús; Oliver T. Bruns; Reinhard Zeidler; Arthur Liesz; Ulrike Protzer; Nikolaus Plesnila; Siegfried Ussar; Farida Hellal; Johannes Paetzold; Markus Elsner; Hendrik Dietz; Ali Erturk ; Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning, Nature Biotechnology, 2025, 1-14
    2.de Souza, N., Zhao, S. & Bodenmiller, B. Multiplex protein imaging in tumour biology. Nat Rev Cancer 24, 171–191 (2024).
    3.Nikita Vladimirov*, Fabian F. Voigt*, Thomas Naert, Gabriela R. Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther Stoeckli, Laura Baudis, Soeren S. Lienkamp, and Fritjof Helmchen. The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples. Nat. commu.,15, 2679 (2024).
    4.Doris Kaltenecker*, Rami Al-Maskari*, Moritz Negwer*, Luciano Hoeher, Florian Kofler, Shan Zhao, Mihail Todorov, Johannes Christian Paetzold, Julia Geppert, Pauline Morigny, Bjoern H. Menze, Stephan Herzig, Mauricio Berriel Diaz, Ali Ertürk. Virtual reality-empowered deep-learning analysis of brain cells. Nature Methods, (2024).
    5.Ruiyao Cai*, Zeynep Ilgin Kolabas*, Chenchen Pan, Hongcheng Mai, Shan Zhao, Doris Kaltenecker, Fabian F. Voigt, Muge Molbay, Tzu-lun Ohn, Cecile Vincke, Mihail I. Todorov, Fritjof Helmchen, Jo A. Van Ginderachter, Ali Ertürk. Whole-mouse clearing and imaging at the cellular level with level with vDISCO. Nature Protocols, 1197–1242 (2023).
    6.Hongcheng Mai*, Zhouyi Rong*, Shan Zhao*, Ruiyao Cai, Hanno Steinke, Ingo Bechmann, Ali Erturk. Scalable SHANEL Tissue Labelling and Clearing for Intact Human Organs. Nature Protocols. 2022, 1-35.
    7.Shan Zhao, Mihail Ivilinov Todorov, Ruiyao Cai, Rami AI-Maskari, Hanno Steinke, Elisabeth Kemter, Hongcheng Mai, Zhouyi Rong, Martin Warmer, Karen Stanic, Oliver Schoppe, Johannes Christian Paetzold, Benno Gesierich, Milagros N. Wong, Tobias B. Huber, Marco Duering, Oliver Thomas Bruns, Bjoern Menze, Jan Lipfert, Victor G. Puelles, Eckhard Wolf, Ingo Bechmann, Ali Ertürk. Cellular and Molecular Probing of Intact Human Organs. Cell, 2020,180,1-17.
    Ruiyao Cai*, Chenchen Pan*, Ghasemigharagoz A, Todorov MI, Forstera B, Zhao S, Bharia HS, Mrowka L, Theodorou D, Rempfle M, Xavier A, Kress BT, Benakis C, Liebscher S, Liesz A, Menze B, Kerschensteiner M, Nedergard M, Erturk A. Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections. Nature Neuroscience (cover), 2019,22,317–327.