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  • 办公地址：

    221, Old Biology Building, Peking University

  • 电子邮箱：

    zhifei.dai@pku.edu.cn
    zhifei.dai@163.com

  • 个人网页：

    http://mimit-pku.org

DAI Zhifei

  • Professor, Doctoral Advisor
  • Boya Distinguished Professor, Department of Biomedical Engineering, College of Future Technology, Peking University
    National Biomedical Imaging Science Center, Peking University
    Vice-Chairman, Molecular Probe and Imaging Technology Branch of China Medical Biotechnology Association
    Vice-Chairman, China Anti-Cancer Association，nano-oncology professional Committee
    Associate Editor, Bioconjugate Chemistry
  • 个人简介
    Professsor Dai's research interests include molecular probes, nanomedicine, and medical ultrasound.
    Representative outcomes include:
    1. Developed a new type of ultrasonic contrast agent "Freivir", and is carrying out phase III clinical trials to solve the technical problem of neck jam. Ultrasus-guided gene therapy technology was developed based on "Frivi", which increased the efficiency of gene delivery by 24 times.
    2. Developed fluorescent molecular imaging probe PKU-800 for surgical navigation, which is expected to apply for clinical trial approval of Class I innovative drugs next year.
    3. Has developed an intelligent ultrasonic diagnostic instrument with nano synergism, which has broad application prospects in the diagnosis and treatment of tumor, cardiovascular disease and brain-related diseases.
  • 所授课程
    Molecular Imaging (Postgraduate)
    Nanomedicine (Undergraduate)
  • 获奖及荣誉
    Recipient of National Natural Science Foundation for Distinguished Young Scholars
    New Century Excellent Talents in Chinese Universities
    Recipient of Natural Science Foundation of Heilongjiang Province for Distinguished Young Scholars
    Baojie Teacher Award
  • 个人履历
    2012 - Present, Professor, Department of Biomedical Engineering, College of Engineering, Peking University, China
    2005 - 2012, Professor, School of Life Science and Technology, Harbin Institute of Technology, China
    2003 - 2005, Postdoctor, Department of Biomedical Engineering, School of Medicine, Emory University, USA
    2000 - 2003, Postdoctor, Max-Planck Institute of Colloids and Interfaces, Germany
    1999 - 2000, Postdoctor, Department of Chemistry, School of Sciences, Kwansei Gakuin University, Japan
    1998 - 1999, Assistant Researcher, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China
    Sep. 1995 – Jul. 1998 Ph.D. in Physical Chemistry, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China
  • 承担项目
    1. Key Project of National Natural Science Foundation of China (No.81930047) : Ultrasound enhanced Atherosclerosis gene therapy (2020.1-2025.12), 2.97 million yuan, under research
    2. International (Regional) Cooperation and Exchange Project of National Natural Science Foundation of China (No. 31961143003) : Study of Ultrasound combined with nanotechnology to improve the curative effect of Prostate Cancer (2019.07-2022.06), 1.75 million yuan, under research
    3. National Major scientific research Instrument development Project (No. 81727803) : Development and application of acoustic diagnosis and treatment system (2018.01 -- 2022.12), 5.7 million yuan, under research
    4. National Key Research and Development Program Nanotechnology Project (No. 2016YFA0201400) : Minimally invasive Cancer Interventional Diagnosis and Treatment Navigation technology based on nanomolecular image probe (2016.07-2021.07), 32 million yuan, concluded
  • 代表性论文及论著
    1. Renfa Liu, Shuai Qu,Yunxue Xu, Hanjoong Jo, Zhifei Dai*. Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance. Signal Transduction and Targeted Therapy, 2022,7,225.
    2. Rui Li, Yiming Zhou, Yijia Liu , Xingpeng Jiang, Wenlong Zeng, Zhuoran Gong, Gang Zheng, Desheng Sun*, Zhifei Dai*. Asymmetric, amphiphilic RGD conjugated phthalocyanine for targeted photodynamic therapy of triple negative breast cancer. Signal Transduction and Targeted Therapy, 2022,7, 64.
    3. Xiaolong Liang, Min Chen, Pravin Bhattarai, Sadaf Hameed, Yida Tang and Zhifei Dai*. Complementing Cancer Photodynamic Therapy with Ferroptosis through Iron Oxide Loaded Porphyrin-Grafted Lipid Nanoparticles. ACS Nano, 2021, 15, 12, 20164–20180.
    4. Xiaolong Liang, Min Chen, Pravin Bhattarai, Sadaf Hameed, and Zhifei Dai*. Perfluorocarbon@Porphyrin Nanoparticles for Tumor Hypoxia Relief to Enhance Photodynamic Therapy against Liver Metastasis of Colon Cancer. ACS Nano, 2020, 14, 10, 13569–13583.
    5. Zhuoran Gong, Min Chen, Qiushi Ren, Xiuli Yue* and Zhifei Dai*. Fibronectin-Targeted Dual-acting Micelles for Combination Therapy of Metastatic Breast Cancer. Signal Transduction and Targeted Therapy, 2020, 5, 12.
    6. Renfa Liu, Jie Tang, Yunxue Xu, Zhifei Dai*, BRET-FRET Nanobubbles for Bioluminescence/Ultrasound Dual-modal Imaging of Inflammation in Vivo, Bioluminescence Imaging of Inflammation in Vivo Based on Bioluminescence and Fluorescence Resonance Energy Transfer Using Nanobubbles Ultrasound Contrast Agent. ACS Nano, 2019, 13(5), 55124-5132.
    7. Yijing Liu, Pravin Bhattarai, Zhifei Dai*, Xiaoyuan Chen*. Photothermal Therapy and Photoacoustic Imaging via Nanotheranostics in Fighting Cancer. Chemical Society Review, 2019, 48, 2053-2108.
    8. Min Chen, Xiaolong Liang, Chuang Gao, Ranran Zhao, Nisi Zhang, Shumin Wang, Wen Chen, Bo Zhao, Jinrui Wang, Zhifei Dai*. Ultrasound Triggered Conversion of Porphyrin/Camptothecin-Fluoroxyuridine Triad Microbubbles into Nanoparticles Overcomes Multidrug Resistance in Colorectal Cancer. ACS Nano, 2018, 12 (7), 7312–7326.
    9. Xiaolong Liang; Chuang Gao; Ligang Cui; Shumin Wang; Jinrui Wang; Zhifei Dai*, Self-assembly of Amphiphilic Janus Camptothecin-Floxuridine Conjugate into Liposome-like Nanocapsules for More Efficacious Combination Chemotherapy in Cancer. Advanced Materials，2017, 29(40), 1703135.
    10. Xiaoyou Wang, Li Lin, Renfa Liu, Min Chen, Binlong Chen, Bo He, Bing He, Xiaolong Liang, Wenbing Dai, Hua Zhang, Xueqing Wang, Yiguang Wang, Zhifei Dai*, Qiang Zhang*, Anisotropy in shape and ligand-conjugation of hybrid nanoparticulates manipulates the mode of bio-nano interaction and its outcome. Advanced Functional Materials, 2017, 27, 1700406.