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  • 办公地址：

    Room 112, Integrated Science Research Center

  • 联系电话：

    010-62768343

  • 电子邮箱：

    chenak@pku.edu.cn

  • 个人网页：

    https://antonychenpku.github.io/

Antony K. Chen

  • Associate Professor (with Tenure), Investigator
  • Department of Biomedical Engineering, National Biomedical Imaging Center (jointly operated)
  • Peking University, Beijing, China
  • 所授课程
    Cellular and Molecular Imaging (UG, 3 credits) Introduction to Biomedical Engineering (G, 3 credits)
  • 教育背景
    B.S. 2000 Bioengineering, University of California, San Diego

    M.S. 2002 Bioengineering, University of California, San Diego (Thesis Advisor: Dr. John A. Frangos)

    Ph.D. 2008 Bioengineering, University of Pennsylvania (Thesis Advisor: Dr. Andrew Tsourkas)


  • 工作简历
    2009.1 – 2010.1 Postdoc, Department of Bioengineering, University of Pennsylvania (Mentor: Dr. Andrew Tsourkas)

    2010.3 – 2012.3 Postdoc, National Institute of Standards of Technology, USA (Mentor: Dr. Anne Plant)

    n 2010.3 – 2013.3 Postdoc, National Institutes of Health, USA (Mentor: Dr. Jennifer Lippincott-Schwartz)

    2013. 4 – 2019.7 Assistant Professor, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China

    2019. 8 – 2021.3 Associate Professor, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China

    2021. 4 – Present Associate Professor, Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China

  • 承担项目
    2021.12 – 2026.6 Principal Investigator, National Key R&D Program of China (No. 2021YFA1100201)

    Title: Developing analytical approaches to decipher dynamic organizations and localizations of membraneless organelles key to stem cell fate determination (RMB 2,764,300)

    2022. 1 – 2025.12 Principal Investigator, National Natural Science Foundation of China (No. 22177001)

    Title: Development and applications of a live-cell imaging platform for intracellular mitochondrial RNA analysis (RMB 600,000)
  • 代表性论文及论著
    1. Qu, N., Ying, Y., Qin, S., and Chen, A.K.* Rational design of self-assembled RNA nanostructures for HIV-1 virus assembly blockade. Nucleic Acids Res. 2022; 50, e44.



    2. Mao, S., Ying, Y., Zhao, M., Yang, Y., and Chen, A.K.* A Background Assessable and Correctable Bimolecular Fluorescence Complementation System for Nanoscopic Single-Molecule Imaging of Intracellular Protein-Protein Interactions. ACS Nano. 2021；15, 14338-14346.



    3. Mao, S., Ying, Y., Wu, R., and Chen, A.K.* Recent Advances in the Molecular Beacon Technology for Live-Cell Single-Molecule Imaging. iScience. 2020; 23, 101801.



    4. Mao, S., Ying, Y., Wu, X., Krueger, C.J. and Chen, A.K.* CRISPR/dual-FRET molecular beacon for sensitive live-cell imaging of non-repetitive genomic loci. Nucleic Acids Res. 2019; 47, e131.



    5. Ding, T., Chen, A.K.* and Lu, Z.* The applications of nanopores in studies of proteins. Sci Bull. 2019; 64, 1456-1467. (Review).



    6. Wu, X., Mao, S., Yachen, Ying., Krueger, C.J. and Chen, A.K.* Progress and Challenges for Live-Cell Imaging of Single Genomic Loci Using CRISPR-Based Platforms. Genomics, proteomics & bioinformatics. 2019; 17(2): 119-128.



    7. Yang, Y., Qu, N., Tan, J., Rushdi, M.N., Krueger, C.J. and Chen, A.K.* Roles of Gag-RNA interactions in HIV-1 virus assembly deciphered by single-molecule localization microscopy. Proc Natl Acad Sci U S A. 2018; 115, 6721-6726.



    8. Wu, X., Mao, S., Yang, Y., Rushdi, M.N., Krueger, C.J. and Chen, A.K.* A CRISPR/molecular beacon hybrid system for live-cell genomic imaging. 2018; Nucleic Acids Res, 46, e80.



    9. Qu, N., Ma, Z., Zhang, M., Rushdi, M.N., Krueger, C.J. and Chen, A.K.* Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation. Protein Cell. 2018; 9, 640-651.



    10. Zhao, D., Yang, Y., Qu, N., Chen, M., Ma, Z. Krueger, C.J., Behlke, M.A. and Chen, A.K.* Single-Molecule Detection and Tracking of RNA Transcripts in Living Cells Using Phosphorothioate-Optimized 2’-O-Methyl RNA Molecular Beacons. Biomaterials. 2016; 100: 172-183.