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HAN Guojun

  • Principal Investigator, Doctoral Advisor
  • Boya Young scholar, International Cancer Institute, Peking University
    Department of Biomedical Engineering, Peking University
    National Biomedical Imaging Center, Peking University
  • 个人简介
    Doctor Han was selected in the Youth Project of the National Overseas Talents Program in 2021. He graduated from the Department of Chemistry, Tsinghua University in 2013, with his supervisor Professor Zhang Xinrong. From 2013 to 2020, he was engaged in the research of the next generation of single-cell mass spectrometry flow cytometry related technologies and clinical medical applications in the research group of Garry Nolan, the founder of single-cell mass spectrometry flow cytometry at Stanford University School of Medicine in Silicon Valley, the United States. He has published more than 30 papers in Nature Communications, Nature Protocols, Cell Reports, Angew Chem and so on. Since 2023, he has served as the chief scientist of the "14th Five-Year" key R&D plan of the Ministry of Science and Technology: the special "intelligent automatic medical flow cytometry" R&D of diagnostic equipment.
    The research directions include the development of single-cell spatial proteomics, metabolomics, transcriptomics and other joint innovative biotechnologies, new methods for analysis, and new reagents for detection, as follows:
    1)Mass spectrometry flow analysis method: single cell multi-omics simultaneous detection and three-dimensional spatial1)Mass spectrometry flow analysis method: single cell multi-omics simultaneous detection and three-dimensional spatial imaging quantitative method;
    2) Synthesis of inorganic nanomaterials: amphiphilic molecular self-assembly nanomaterials as protein and metabolic molecular probes;
    3) Organic polymer synthesis: nucleic acid-labeled probes for biocompatible polymeric metal chelating ligands;
    4) Bioinformatics: single-cell clinical data dimensionality reduction, clustering, cell image segmentation, spatial analysis.
  • 所授课程
    Seminar on Advances in Biomedical Engineering (Compulsory, 3 credits)
    Introduction to Medical Technology (Compulsory, 3 credits)
    Oral Biomedical Engineering (Compulsory, 3 credits)
  • 获奖及荣誉
    Outstanding Youth Fund (Overseas), National Natural Science Foundation
    Chief Scientist, "14th Five-Year Plan" Key Research and Development Program, Ministry of Science and Technology
  • 个人履历
    2020.04-present Principal Investigator, Peking University Health Science Center
    2018.09-2020.03 Principal Investigator, Stanford University School of Medicine, USA
    2013.09-2018.08 Postdoctoral Research Scholar, Stanford University School of Medicine, USA
    2009.09-2013.08 Ph. D. Department of Chemistry, Tsinghua University
  • 团队成员
    Yang Zhao, Assistant researcher
    Wu Wenying, Assistant Researcher
    Kong Ran, Assistant researcher
    Li Mingrui, Assistant researcher
  • 承担项目
    Key Research and Development Plan of the Ministry of Science and Technology (2022YFC2406300), 2023-2027, hosy
    Outstanding Youth Science Foundation Project (Overseas), 2022-2024, host
    Surface Project (22174004), 2022-2025, Host
    Innovation Group Project (82221003), 2023-2027, Backbone
    The 8th Instrument Creation and Key Technology Research and Development Project of Peking University, 2022-2023, presided over
    "Clinical Medicine +X" Youth Project, Peking University, 2022-2023, host
    "Clinical Medicine +X" Youth Project, Peking University, 2021-2022, host
    Laboratory Open Project, School of Stomatology, Peking University, 2023-2024, Host
  • 代表性论文及论著
    1. Shen, ZZ; Zhao HS, Yao H; Pan, XY; Yang, JL; Zhang, SC*; Guojun Han*; Zhang XR. Dynamic metabolic change of cancer cells induced by natural killer cells at the single-cell level studied by label-free mass cytometry, Chemical Science, 2022, 3;13(6):1641-1647.
    2. Coskun. A. F.#*; Guojun Han#; Ganesh S.; Chen S.; Clavé X. R.; Harmsen S.; Jiang S. ; Schürch C. M.; Bai Y.; Hitzman C.; Nolan G. P.*; Nanoscopic subcellular imaging enabled by ion beam tomography, Nature Communications, 2021, 12(789).
    3. Guojun Han, Matthew Spitzer, Sean Bendall, Wendy Fantl, Garry P Nolan, Metal isotope-tagged monoclonal antibodies for high-dimensional mass cytometry, Nature Protocols 2018, 13, 2121-2148. (Week’s FREE Featured Article)
    4. Guojun Han, Shih‐Yu Chen, Veronica Gonzalez, Eli Zunder, Wendy Fantl, Garry Nolan, Atomic mass tag of bismuth‐209 for increasing the immunoassay multiplexing capacity of mass cytometry, Cytometry Part A 2017, 91 (12), 3462-3465.
    5. Guojun Han; Zhang, SC; Xing, Z; Zhang, XR, Absolute and Relative Quantification of Multiplex DNA Assays Based on an Elemental labeling Strategy. Angewandte Chemie. International Edition 2013, 52 (5), 1466 -1471.
    6. Guojun Han; Xing, Z; Dong, YH; Zhang, SC; Zhang, XR, One-Step Homogeneous DNA Assay with Single-Nanoparticle Detection. Angewandte Chemie. International Edition 2011, 50 (15), 3462-3465.
    7. Liu, YY; Ma, XX; Lin, ZQ; He, MJ; Guojun Han; Yang, CD; Xing, Z; Zhang, SC; Zhang, XR, Imaging Mass Spectrometry with a Low Temperature Plasma Probe for the Analysis of Works of Art. Angewandte Chemie. International Edition 2010, 49 (26), 4435-4437.