• Associant Professor
• School of Electronics, Peking University
  National Biomedical Imaging Center

• 个人简介

  The research interests of the laboratory are focused on a series of research topics based on waveguide optics and ultrafast optics, including special microstructure fibers, ultrafast fiber lasers, fiber sensors, and multimode bio-optical imaging microscopy based on them. Dr. Wang has 20 years of research experience in the above fields, and has published more than 50 international journal articles and book chapters. He has supported and participated in a number of national research projects, including the National Natural Science Foundation, the National High Technology 863 Project, the major instrument of the Ministry of Science and Technology, and the key research and development program.
  Core research areas and achievements are as follows:
  Ultrafast laser and core special fiber devices: Special fiber including soft glass photonic crystal fiber, high birefringence fiber, hollow photonic crystal fiber and other different microstructure fiber design, manufacturing, characterization, post-processing and related applications, and has made innovative leading results in this field; Ultrafast fiber laser technology includes special wavelength infrared region I/II multi-photon imaging fiber femtosecond laser, high frequency fiber femtosecond laser, GHz high precision fiber laser frequency comb and astronomical comb application, etc. : The repetition rate of the NPE-based Yb fiber ring laser has been successfully raised to the world record level of GHz by designing and making new fiber elements. Design and manufacture of the world's first fully positive dispersive Nd fiber 920nm femtosecond laser. The newly designed 780nm femtosecond laser has passed the space launch test standards.
  Multi-photon biological microscopic imaging: It mainly focuses on the research of miniaturized two-photon microscope imaging system based on hollow fiber, miniaturized objective lens and femtosecond laser. For the first time in the world, the dynamic activity imaging of brain neurons and synapses in free-moving mice was realized, and the Nature Methods of the Year 2018 was awarded. In the large three-photon technology, the three-photon breakthrough of high speed volume imaging is realized by using Bessel light =. This year, we achieved a breakthrough in miniminization three-photon microscope. The probe weight is 2.17g, which can maximize the collection efficiency of scattered fluorescence. It is suitable for non-invasive recording of the neuronal activity of the whole cerebral cortex and dorsal hippocampus in mice with free behavior, with safe laser power and high imaging quality comparable to that of desktop three-photon microscope. In recent years, the handheld skin two-photon microscope system based on human in vivo fluorescence has passed the space launch standard, and further realized clinical application and promotion.

• 所授课程

  Femtosecond Optics (Optional, 3 credits)

• 获奖及荣誉

  2017: Ten scientific and technological advances, Ministry of Science and Technology
  2013: Selected into the "Young Talents Program" of Beijing Higher Education Institutions

• 个人履历

  2012/08-present: School of Electronics, Peking University, Associate Professor
  2010/07-2012/07: Peking University, School of Information Science and Technology, Lecturer
  2008/07-2010/06: Postdoctoral Researcher, School of Physics, Peking University
  2007/05-2008/06: Beijing Huatuo Guangyan Technology Co., LTD., R&D Manager
  October 2003 - February 2007: University of Bath, UK, PhD in Physics
  September 1999 -- July 2002: Peking University, Optics, Master
  1995/09-1999/07: Peking University, Physics, Bachelor Degree

• 承担项目

  1. Key Research and Development Plan of the Ministry of Science and Technology (2020/6-2023/5) : Project: Efficient flexible optical fiber transmission technology of high power femtosecond laser for surgery (Project: femtosecond laser Minimally invasive Surgical robot System), Project leader, fund: 2.29 million
  2. Natural Science Foundation of China (2020/1-2023/12) : Research on Miniaturized three-photon imaging of the whole cerebral cortex of free-moving mice (Project No. : 61975002), Project leader, Fund: 630,000 Yuan
  3. Key Project of Natural Science Foundation: "New Techniques and Methods for the Study of Brain Functional connectomics" (Approval number: 31830036), Principal of Peking University, Fund: 1.18 million

• 代表性论文及论著

  1. Zong, W., Wu, R., Chen, S. Shiyuan Chen, Junjie Wu, Hanbin Wang, Zhe Zhao, Guoqing Chen, Rui Tu, Danlei Wu, Yanhui Hu, Yangyang Xu, Yao Wang, Zhuoli Duan, Haitao Wu, Yunfeng Zhang, Jue Zhang, Aimin Wang, Liangyi Chen，Heping Cheng，“Miniature two-photon microscopy for enlarged field-of-view, multi-plane and long-term brain imaging”. Nature Methods 18, 46–49 (2021).
  2. Weijian Zong, Runlong Wu, Mingli Li, Yanhui Hu, Yijun Li, Jinghang Li, Hao Rong, Haitao Wu, Yangyang Xu, Yang Lu, Hongbo Jia, Ming Fan, Zhuan Zhou, Yunfeng Zhang, Aimin Wang*, Liangyi Chen, Heping Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice” , Nature Methods, 14(7), 713–719 (2017).
  3. Bingying Chen, Xiaoshuai Huang, Dongzhou Gou, Jianzhi Zeng, Guoqing Chen, Meijun Pang, Yanhui Hu, Zhe Zhao, Yunfeng Zhang, Zhuan Zhou, Haitao Wu, Heping Cheng, Zhigang Zhang, Chris Xu, Yulong Li, Liangyi Chen, and Aimin Wang, Rapid volumetric imaging with Bessel-Beam three-photon microscopy, Biomedical Optics Express, 9(4), 1992-2000（2018）.
  4. Bingying Chen, Hao Rong, Runlong Wu, Yijun Li, Zhigang Zhang, Liangyi Chen, Aimin Wang, “Robust hollow-fiber-pigtailed 930 nm femtosecond Nd:fiber laser for volumetric two-photon imaging,” Opt. Express, 25 22704-22709 (2017).
  5. Chen Li, Yuxuan Ma, Xiang Gao, Fuzeng Niu, Tongxiao Jiang, Aimin Wang*, Zhigang Zhang, "1 GHz repetition rate femtosecond Yb:fiber laser for direct generation of carrier-envelope frequency offset beating signals”, Applied Optics, 54(28) 8350-8353 (2015). (WOS: 000362237300056).