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CHEN Lei

  • Research Professor,
    Investigator, Peking University Boya Young Fellow


  • Peking-Tsinghua Center for Life Sciences, National Biomedical Imaging Center (jointly operated)
  • 个人简介
    Dr. Zhixing Chen is a chemist with research experience spanning natural product synthesis, polymer mechano-chemistry, fluorescence and non-linear optical probes, bioconjugation, and live cell imaging. Zhixing believes in the enabling role of molecular technologies at the frontier of optical imaging, biotechnology, and life sciences. His current focus is to develop small and macro molecular tools for advanced imaging technologies. In the long term, Zhixing endeavors to unleash the synergy at the chemistry-biology-imaging interface in a collaborative manner, bringing new dimensions to the fields of molecular imaging and molecular medicine.
  • 所授课程
    Recent advance in bioimaging probes (3 credits)

    , Frontiers in Chemical Biotechnology and Bioimaging (3 credits)

    , General Chemistry (UG, 2 credits)

  • 教育背景
    Ph.D. 2009-2014 Chemistry Department of Chemistry, Columbia University
    , B.S. 2004-2008 Chemical Biology Department of Chemistry, Tsinghua University
  • 工作简历
    2018- now CLS Investigator, Peking-Tsinghua Center for Life Sciences, Peking University

    Assistant Professor, Institute of Molecular Medicine, College of Future Technology, Peking University

    , 2016-2018 Postdoctoral Researcher, Department of Chemistry, Stanford University (Advisor: Professor Yan Xia)

    , 2015 Postdoctoral Researcher, Department of Chemistry, Columbia University (Advisor: Professor Wei Min)

    , 2008-2009 Research Assistant, College of Chemistry and Molecular Engineering, PKU (Advisors: Professors Zhen Yang and Jiahua Chen)
  • 承担项目
    Beijing Municipal Science & Technology Commission

    , National Natural Science Foundation of China (General Program)
  • 代表性论文及论著
    1. Zhang, J. #, Peng, X. #, Wu, Y. #, Ren, H. #, Sun, J., Tong, S., Liu, T., Zhao, Y., Wang, S., Tang, C., Chen, Z.*, Red- and Far-Red-Emitting Zinc Probes with Minimal Phototoxicity for Multiplexed Recording of Orchestrated Insulin Secretion. Angew. Chem. Intl. Ed. In press (2021).

    2. Yang, Z.#, Li, L.#, Ling, J., Liu, T., Huang, X., Ying, Y., Zhao, Y., Zhao, Y., Lei, K.*, Chen, L.*, Chen, Z.*, Cyclooctatetraene-conjugated cyanine mitochondrial probes minimize phototoxicity in fluorescence and nanoscopic imaging. Chem. Sci. 11, 8506-8516(2020).

    3. Chen, Z., Mercer, J. A. M., Zhu, X., Romaniuk, J. A. H., Pfattner, R., Cegelski, L., Martinez, T. J., Burns, N. Z., Xia, Y. Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene. Science 357, 475-479 (2017) [Front Cover].

    4. Wei, L., Chen, Z., Shi, L., Long, R., Anzalone, A. V., Zhang, L., Hu, F., Yuste, R., Cornish, V. W., Min, W. Super-multiplex vibrational imaging. Nature 2017, 544, 465-470.

    5. Chen, Z., Paley, D. W., Wei, L., Weisman, A. L., Friesner, R. A., Nuckolls, C., Min, W. Multicolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational Palette. J. Am. Chem. Soc. 2014, 136, 8027–8033.

    6. Chen, Z., Jing, C., Gallagher, S. S., Sheetz, M. P., Cornish, V. W. Second-Generation Covalent TMP-Tag for Live Cell Imaging. J. Am. Chem. Soc. 2012, 134, 13692–13699.