中文
中文
Faculty
Home >> Faculty >> Researchers

CHEN Lei

  • Principal Investigator, Ph.D. Advisor
  • Institute of Molecular Medicine, College of Future Technology, Peking University
    Center for Life Sciences, Peking University - Tsinghua University
    National Biomedical Imaging Science Center, Peking University
  • 个人简介
    Dr. Chen’s research focuses on elucidating the structural mechanisms of proteins implicated in human diseases, particularly cardiovascular and metabolic disorders. His laboratory has successfully determined the structures of several critical drug targets, including the metabolic sensor KATP channel, the nitric oxide receptor soluble guanylate cyclase, and the glucose transporter SGLT2.
  • 所授课程
    Protein structure analysis (1 credit)
    Progress on research of ion channel gating mechanism (2 credits)
    Progress on Research of Membrane Proteins (2 credits)
  • 获奖及荣誉
    National Outstanding Young Scholar
  • 教育背景
    2001-2005 Bs Biology, Tsinghua University
    2005-2010 Ph. D. Biology, Tsinghua University
  • 工作简历
    2010–2016 Postdoc, Oregon Health and Science University
    2006–2021 Investigator, Institute of Molecular Medicine, Peking University
    2021– now Investigator, College of Future Technology, Peking University
  • 代表性论文及论著
    1. Guo, W., Tang, Q., Wei, M., Kang, Y., Wu, J. X., and Chen, L. (2022) Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites, Neuron.
    2. Niu, Y., Liu, R., Guan, C., Zhang, Y., Chen, Z., Hoerer, S., Nar, H., and Chen, L. (2021) Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter, Nature 601, 280-284.
    3. Kang Y.*, Liu R.*, Wu J. X.,Chen L. Structural insights into the mechanism of human soluble guanylate cyclase. Nature (2019), 574, 206-210.
    4. Zhang, M., Wang, D., Kang, Y., Wu, J.X., Yao, F., Pan, C., Yan, Z.#, Song, C.#, and Chen, L.# (2018). Structure of the mechanosensitive OSCA channels. Nature structural & molecular biology 25, 850-858.
    5. Li, N.*, Wu, J.X.*, Ding, D., Cheng, J., Gao, N.#, and Chen, L#. (2017). Structure of a Pancreatic ATP-Sensitive Potassium Channel. Cell 168, 101-110 e110.(# Co-corresponding author)