• School of Future Technology, Peking University
  
  National Biomedical Imaging Center, Peking University

• 个人简介

  Dr. Chang’s research focuses on the gut-brain axis and brain-body communications, with particular emphasis on how neural circuits regulate gastrointestinal function and how stress, emotion, and the gut microbiota influence each other bidirectionally. His work aims to uncover how the central nervous system senses and modulates the gastrointestinal environment via pathways such as the vagus nerve, and to elucidate the roles of the brain–gut–microbiota system in metabolic disorders, inflammatory bowel disease, and mood-related conditions.
  
  Dr. Chang takes a multidisciplinary approach, integrating neurogenetics, molecular biology, super-resolution imaging, and AI-based neural network modeling to systematically investigate gut-brain signaling across multiple spatial and temporal scales. He has published as first or corresponding author in leading international journals including Cell, Nature Methods, and PNAS.
  

• 所授课程

  Frontiers in Neuroscience Research Techniques (Core Course, 2 scores)

• 教育背景

  2008–2013: Ph.D. in Cell Biology, Institute of Biophysics, Chinese Academy of Sciences
  
  2004–2008: B.Sc. in Biological Sciences, University of Science and Technology of China

• 工作简历

  2025.03–Present: Assistant Professor / Principal Investigator, School of Future Technology & National Center for Biomedical Imaging Center, Peking University
  
  2024.01–2025.03: Assistant Professor (Research Track), Icahn School of Medicine at Mount Sinai
  
  2020.01–2024.01: Postdoctoral Fellow, Icahn School of Medicine at Mount Sinai
  
  2013.12–2020.01: Postdoctoral Fellow, Yale School of Medicine

• 代表性论文及论著

  1. Chang, Hao; Perkins, Matthew H.; Novaes, Leonardo S.; Qian, Feng; Zhang, Tong; Neckel, Peter H.; Scherer, Simon; Ley, Ruth E.; Han, Wenfei; Araujo, Ivan E. de ; Stress-sensitive neural circuits change the gut microbiome via duodenal glands, Cell, 2024, 187(19): 5393-5412
  2. Liu, Bohan; Chang, Hao; Yang, Dong; Yang, Feifei; Wang, Qiushuang; Deng, Yujiao; Li, Lijun; Lv, Wenqing; Zhang, Bo; Yu, Liheng; Burkhoff, Daniel; He, Kunlun ; A deep learning framework assisted echocardiography with diagnosis, lesion localization, phenogrouping heterogeneous disease, and anomaly detection, Scientific Reports, 2023, 13(1)
  3. Mei Han; Matthew H. Perkins; Leonardo Santana Novaes; Tao Xu; Hao Chang ; Advances in transposable elements: from mechanisms to applications in mammalian genomics, Frontiers in Genetics, 2023, 14
  4. Zhang, Tong; Perkins, Matthew H.; Chang, Hao; Han, Wenfei; de Araujo, Ivan E. ; An inter-organ neural circuit for appetite suppression, Cell, 2022, 185(14): 2478
  5. Chang, Hao; Pan, Yukun; Landrette, Sean; Ding, Sheng; Yang, Dong; Liu, Lufang; Tian, Lei; Chai, Hongyan; Li, Peining; Li, Da-Ming; Xu, Tian ; Efficient genome-wide first-generation phenotypic screening system in mice using the piggyBac transposon., Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(37): 18507-18516
  6. Han, Mei; Zou, Wenjuan; Chang, Hao; Yu, Yong; Zhang, Haining; Li, Shitian; Cheng, Hankui; Wei, Guifeng; Chen, Yan; Reinke, Valerie; Xu, Tao; Kang, Lijun ; A Systematic RNAi Screen Reveals a Novel Role of a Spindle Assembly Checkpoint Protein BuGZ in Synaptic Transmission in C. elegans, Frontiers in Molecular Neuroscience, 2017, 10: 0-141
  7. Chang, Hao; Han, Mei; Huang, Wenming; Wei, Guifeng; Chen, Juanjuan; Chen, Peng R.; Chen, Runsheng; Zhang, Junlong; Xu, Tao; Xu, Pingyong ; Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans, Protein & Cell, 2013, 4(12): 883-886
  8. Zhang, Mingshu; Chang, Hao; Zhang, Yongdeng; Yu, Junwei; Wu, Lijie; Ji, Wei; Chen, Juanjuan; Liu, Bei; Lu, Jingze; Liu, Yingfang; Zhang, Junlong; Xu, Pingyong; Xu, Tao ; Rational design of true monomeric and bright photoactivatable fluorescent proteins, Nature Methods, 2012, 9(7): 727-U297
  9. Chang, Hao; Zhang, Mingshu; Ji, Wei; Chen, Juanjuan; Zhang, Yongdeng; Liu, Bei; Lu, Jingze; Zhang, Junlong; Xu, Pingyong; Xu, Tao ; A unique series of reversibly switchable fluorescent proteins with beneficial properties for various applications, Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(12): 4455-4460