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LIU Zhibo

  • Professor, Doctoral Advisor
  • College of Chemistry and Molecular Engineering, Peking University
    National Biomedical Imaging Center, Peking University
    Center for Life Sciences, Peking University-Tsinghua University
  • 个人简介
    Zhibo Liu's research group (College of Chemistry and Molecular Engineering, Peking University & Center for Life Sciences, Peking-Tsinghua) has carried out research in molecular imaging, radioactive drugs, neutron capture therapy and other frontier areas. In recent years, he has presided over many research projects, including the State Key Research and Development Program of the Ministry of Science and Technology, the Key Project of the National Natural Science Foundation of China. He has published more than 60 papers, including Nature, JACS, Angewandte Chemie, etc., which have been featured in Science, Nature Reviews Immunology, C&EN News and other magazines. Several nuclear drug molecules have been carried out clinical research.
    Research Interests:
    Biochemistry and its driving forces in protein activation and drug release;
    Imaging diagnostic probes and clinical translational research of rare diseases;
    Neutron-capture therapeutic drugs and their radiation biological effects;
    Production technology research and clinical application of new medical nuclides.
  • 所授课程
    General Chemistry B (Compulsory, 4 credits)
    Chemistry Today (Elective, 1 credit)
    Introduction to Medicinal Chemistry (Elective, 2 credits)
    Fundamentals of Life Science Experiments (Elective, 3 credits)
  • 获奖及荣誉
    2022, Recipient of the National Natural Science Foundation of China Outstanding Youth Fund
    2021, Best Preclinical Publication Award, the 9th World ADC Annual Meeting
    2021, Ones-to-Watch, Society of Nuclear Medicine and Molecular Imaging
    2020, Youth Chemistry Award, Chinese Chemical Society
    2019, Biochemistry Young Scholar Award, Wuxi Apptec
    2019, First prize in the Basic Teaching Skills Competition of Peking University Young Teachers
    2018, Fairchild Award, 18th International Congress of Neutron Capture Therapy
    2018, Green-Leaf Biology Young Scientist Award, Peking University
    2016, Distinguished Scientist Award, NIH-CSSA Committee
    2015, Michael J. Welch Postdoctoral Award, Society of Nuclear Medicine and Molecular Imaging
    2015, JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging
    2015, Alavi-Mandell Award, Society of Nuclear Medicine and Molecular Imaging
    2014, Edward Piers Memorial Award, Edward Piers Foundation
    2014, Chinese Government Award for Outstanding Abroad Students, China Scholarship Council
    2013, Young Investigator Award, 37th CASNMMI
    2013, Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation
  • 个人履历
    2016.07-present Assistant Professor and Associate Professor, College of Chemistry and Molecular Engineering, Peking University
    2016.07-present Principal Investigator, Center for Life Sciences, Peking University-Tsinghua University
    2014.09-2016.07 Postdoctoral Researcher, National Institutes of Health
    2010.09-2014.09 Ph. D. Department of Chemistry, University of British Columbia, Canada
    2006.09-2010.06 BE School of Chemistry and Chemical Engineering, Nanjing University,
  • 团队成员
    Ding Zexuan, Associate Researcher
    Cui Xiyang, Associate Researcher
    Han Yuxiang, Associate Researcher
    Chen Jie, Secretary
  • 承担项目
    1. National Natural Science Foundation of China Outstanding Youth Fund Project, radiopharmaceutical Chemistry
    2. Young Scientist Project of the National Key Research and Development Program of the Ministry of Science and Technology, accurate activation technology of ion beamguided functional molecules in vivo based on radiation shear chemistry
    3. Key project of the National Natural Science Foundation of China, Study on the uptake mechanism of novel boron neutron capture therapy drug with molecular image assistance and characterization of therapeutic beam quality
    4. National Natural Science Foundation project, research on molecular probe for early cancer diagnosis targeting glycine decarboxylase
    5. Key project of Beijing Natural Science Foundation, Molecular Imaging and mechanism research of islet beta cells based on artificial intelligence
    6. Innovation Project of Sunan Research Institute, Peking University
    7. Li Ge-Zhao Ning Youth Research Fund for Life Sciences
    8. "Clinical Medicine + X" Fund youth project, Peking University
  • 代表性论文及论著
    1. Qinyang Wang#, Yupeng Wang#, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426.
    2. Zhibin Guo#, Hanyu Hong#, Yuedan Zheng, Ziyang Wang, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Radiotherapy-Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors. Angew Chem Int Ed, 2022, doi: 10.1002/anie.202205014.
    3. Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu*. A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation. ACS Cent Sci, 2022, 8,837.
    4. Jiyuan Li#, Qi Sun#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*, Boron Encapsulated In A Liposome Can Be Used for Combinational Neutron Capture Therapy. Nat Commun, 2022, 13, 2143.
    5. Zexuan Ding, Zhibin Guo, Yuedan Zheng, Ziyang Wang, Qunfeng Fu, Zhibo Liu*, Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors, J. Am. Chem. Soc., 2022, doi.org/10.1021/jacs.2c02521.
    6. Chunhong Wang, Hanyu Hong, Mengqi Chen, Zexuan Ding, Yuchen Rui, Zi-Chen Li, Zhibo Liu*, Cationic Micelle as An In Vivo Catalyst for Tumor-Localized Cleavage Chemistry. Angew. Chem. Int. Ed., 2021, 60, 19750–19758.
    7. Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*, Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo. J. Am. Chem. Soc., 2021, 143, 2250–2255.
    8. Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*, External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors, Angew. Chem. Int. Ed., 2020, 59, 21546-21552.
    9. Pu Zhang#, Mengxin Xu#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*，Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy, Eur. J. Nucl. Med. Mol. Imaging, 2022, 49, 1985-1996.
    10. Mengxin Xu#, Pu Zhang#, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu*, Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy. J. Nucl. Med., 2021, doi: 10.2967/jnumed.121.262533.